Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470418 | 0.90 | MAPK1 (0.65) | MAPK1SMN1; SMN2HTTEGFRMEN1 | |
| SCHEMBL7465161 | 0.89 | PDE5A (0.52) | MAPK1SMN1; SMN2HTTEGFRMEN1 | |
| SCHEMBL7462734 | 0.87 | EGFR (0.55) | MAPK1HTTEGFRMEN1KMT2A | |
| SCHEMBL7474181 | 0.86 | MAPK1 (0.56) | MAPK1SMN1; SMN2HTTEGFRMAPT | |
| SCHEMBL7464129 | 0.86 | MAPK1 (0.69) | MAPK1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL7470831 | 0.85 | EGFR (0.53) | MAPK1HTTEGFRMAPTCLK4 | |
| SCHEMBL7475626 | 0.82 | HTT (0.52) | MAPK1SMN1; SMN2HTTEGFRMEN1 | |
| SCHEMBL7471567 | 0.82 | PIK3CD (0.62) | MAPK1HTTEGFRTP53MAPT | |
| SCHEMBL7467721 | 0.82 | MEN1 (0.45) | MAPK1SMN1; SMN2HTTEGFRMEN1 | |
| SCHEMBL7465156 | 0.82 | MAPK1 (0.53) | MAPK1SMN1; SMN2HTTEGFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |