Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473060 | 0.89 | STAT1 (0.64) | PDE5AMAPK1HTTSTAT1RAF1 | |
| SCHEMBL7474668 | 0.84 | HTT (0.63) | PDE5AMAPK1HTTLMNAKDM4E | |
| SCHEMBL7465102 | 0.84 | PDE5A (0.54) | PDE5AMAPK1KDM4EALDH1A1MEN1 | |
| SCHEMBL7465501 | 0.84 | STAT1 (0.56) | PDE5AMAPK1HTTSTAT1RAF1 | |
| SCHEMBL7470465 | 0.83 | MAPK1 (0.66) | MAPK1HTTLMNAKDM4EEGFR | |
| SCHEMBL7470418 | 0.82 | MAPK1 (0.65) | PDE5AMAPK1HTTRAF1LMNA | |
| SCHEMBL7472816 | 0.81 | EGFR (0.48) | MAPK1HTTRAF1KDM4EEGFR | |
| SCHEMBL7464129 | 0.81 | MAPK1 (0.69) | PDE5AMAPK1HTTSTAT1LMNA | |
| SCHEMBL7466553 | 0.81 | STAT1 (0.52) | PDE5AMAPK1HTTSTAT1RAF1 | |
| SCHEMBL7473136 | 0.81 | STAT1 (0.52) | PDE5AMAPK1HTTSTAT1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |