SCHEMBL7470783

SCHEMBL7470783

CC(=O)C(C(N)=O)c1c(CF)cccc1C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.37
MAOA P21397 1/20 0.37
POLQ O75417 1/20 0.36
POLB P06746 1/20 0.35
MAPK1 P28482 1/20 0.35
AURKA O14965 1/20 0.35
RPS6KB1 P23443 1/20 0.35
AURKB Q96GD4 1/20 0.35
ALDH1A1 P00352 2/20 0.35
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34
IDO1 P14902 2/20 0.34
EPHX1 P07099 1/20 0.34
CD38 P28907 2/20 0.34
CYP3A4 P08684 1/20 0.34
NOTUM Q6P988 1/20 0.33
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33
ATM Q13315 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7463293 0.81 SCN9A (0.39) CTSSCTSKCD38CYP3A4NOTUM
SCHEMBL15373348 0.75 P2RX7 (0.39) MAOBPOLQPOLBMAPK1ALDH1A1
SCHEMBL7471669 0.72 ACP3 (0.44) MAOBMAOAPOLBMAPK1ALDH1A1
SCHEMBL7676477 0.69 AKR1C3 (0.41) POLQNOTUM
SCHEMBL7479581 0.68 CES2 (0.44) EPHX1NOTUMGAA
SCHEMBL3647884 0.66 IDO1 (0.59) MAOBMAOAPOLQPOLBALDH1A1
SCHEMBL24517077 0.66 MAOB (0.46) MAOBMAOAPOLQPOLBMAPK1
SCHEMBL6695640 0.66 PPARG (0.51) MAOBMAOAPOLQPOLBMAPK1
SCHEMBL27761205 0.66 MAOB (0.49) MAOBMAOAPOLQIDO1GAA
SCHEMBL16664440 0.66 LMNA (0.39) MAOBMAOAPOLQPOLBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077701-A4 ANTI-VIRAL COMPOUNDS LILLY CO ELI (US) 2002-03-20 EP disclosed
US-6358971-B1 FOR INHIBITING THE GROWTH OF A PICORNAVIRUS ELI LILLY AND COMPANY 2002-03-19 US disclosed
EP-1077701-A1 ANTI-VIRAL COMPOUNDS ELI LILLY AND COMPANY (US) 2001-02-28 EP disclosed
WO-1999059587-A1 ANTI-VIRAL COMPOUNDS ELI LILLY AND COMPANY (US) 1999-11-25 WO disclosed