Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.44 |
| ▸ | CES1 | P23141 | 4/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463293 | 0.85 | SCN9A (0.39) | CES2CES1NOTUM | |
| SCHEMBL7683035 | 0.84 | CES2 (0.44) | CES2CES1BCHEITGB2ICAM1 | |
| SCHEMBL29718627 | 0.78 | CES2 (0.46) | CES2CES1BCHEEPHX1ITGB2 | |
| SCHEMBL1723267 | 0.77 | NLRP3 (0.43) | CES2CES1GAAKMT2A | |
| SCHEMBL7464198 | 0.75 | CES2 (0.62) | CES2CES1BCHEEPHX1ITGB2 | |
| SCHEMBL13170115 | 0.75 | CES2 (0.62) | CES2CES1BCHEALBERN1 | |
| SCHEMBL7469784 | 0.74 | LMNA (0.32) | — | |
| SCHEMBL5250437 | 0.74 | CES2 (0.50) | CES2CES1BCHEITGB2ICAM1 | |
| SCHEMBL5254396 | 0.73 | MAPK1 (0.39) | CES2CES1ITGB2ICAM1ITGAL | |
| SCHEMBL14491951 | 0.71 | CES2 (0.40) | CES2CES1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6358971-B1 | FOR INHIBITING THE GROWTH OF A PICORNAVIRUS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |