Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6738290 | 0.76 | THRB (0.43) | DRD2DRD3THRBKCNH2 | |
| SCHEMBL7471276 | 0.71 | HRH3 (0.41) | DRD2DRD3THRBKCNH2 | |
| SCHEMBL7036576 | 0.65 | KMT2A (0.57) | KCNH2 | |
| SCHEMBL10410778 | 0.65 | FUCA1 (0.42) | DRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL14559918 | 0.64 | HTR1A (0.51) | DRD2DRD3 | |
| SCHEMBL14559976 | 0.62 | DRD2 (0.49) | DRD2DRD3 | |
| SCHEMBL2955795 | 0.62 | FUCA1 (0.60) | CHRM2CHRM4CHRM5 | |
| SCHEMBL9521157 | 0.62 | ALDH1A1 (0.54) | CHRM4 | |
| SCHEMBL6621574 | 0.61 | KMT2A (0.41) | KCNH2 | |
| SCHEMBL7032692 | 0.60 | CTSK (0.50) | CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |