Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460713 | 0.85 | MAPK8 (0.55) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL7463851 | 0.85 | NOX4 (0.46) | CMA1MAPK8MAPK9PARGALDH1A1 | |
| SCHEMBL7461329 | 0.84 | CMA1 (0.46) | CMA1MAPK8MAPK9ALDH3A1CXCL8 | |
| SCHEMBL7467427 | 0.80 | ALDH1A1 (0.47) | CMA1MAPK8MAPK9ALDH3A1PSEN1 | |
| SCHEMBL7466124 | 0.79 | CMA1 (0.46) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL7466686 | 0.78 | CYP3A4 (0.38) | CMA1MAPK8MAPK9ALDH3A1NOD2 | |
| SCHEMBL7472819 | 0.77 | HSP90AA1 (0.39) | CMA1MAPK8NOD2NOD1HDAC6 | |
| SCHEMBL4456863 | 0.77 | GABRA5 (0.53) | CMA1MAPK8MAPK9PARGSMN1; SMN2 | |
| SCHEMBL7468517 | 0.77 | HDAC6 (0.52) | CMA1MAPK8MAPK9HDAC6HDAC1 | |
| SCHEMBL7462052 | 0.77 | KMT2A (0.47) | CMA1MAPK8MAPK9HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |