Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482004 | 0.86 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTLMNAMEN1 | |
| SCHEMBL7472363 | 0.85 | L3MBTL1 (0.49) | ALDH1A1SMN1; SMN2RAB9AMAPTMEN1 | |
| SCHEMBL7474643 | 0.85 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL7482260 | 0.84 | KCNA3 (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL7471334 | 0.84 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2NPSR1NPC1RAB9A | |
| SCHEMBL7476927 | 0.82 | HDAC8 (0.55) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL7483118 | 0.81 | NR1H4 (0.44) | SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL7478056 | 0.81 | KMT2A (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL7480996 | 0.81 | RAB9A (0.56) | ALDH1A1SMN1; SMN2NPSR1NPC1RAB9A | |
| SCHEMBL7478227 | 0.81 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2NPSR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |