Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482004 | 0.87 | ALDH1A1 (0.46) | L3MBTL1MMP9MMP8ALDH1A1MMP2 | |
| SCHEMBL7472887 | 0.85 | ALDH1A1 (0.48) | L3MBTL1ATMTDP1ALDH1A1HTT | |
| SCHEMBL7471334 | 0.85 | SMN1; SMN2 (0.52) | L3MBTL1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7482260 | 0.85 | KCNA3 (0.48) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL7476927 | 0.83 | HDAC8 (0.55) | MMP9MMP8ALDH1A1MMP2MEN1 | |
| SCHEMBL7475904 | 0.83 | MEN1 (0.47) | TDP1ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL7483118 | 0.82 | NR1H4 (0.44) | MMP9MMP8CTSLMEN1KMT2A | |
| SCHEMBL7477672 | 0.82 | LMNA (0.53) | TDP1ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL7480996 | 0.82 | RAB9A (0.56) | TDP1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7478056 | 0.82 | KMT2A (0.46) | L3MBTL1ALDH1A1KDM4EHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |