Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FABP1 | P07148 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480996 | 0.89 | RAB9A (0.56) | NPC1SMN1; SMN2RAB9AKAT6AALDH1A1 | |
| SCHEMBL7475904 | 0.87 | MEN1 (0.47) | NPC1SMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL7478227 | 0.86 | ALDH1A1 (0.50) | NPC1SMN1; SMN2RAB9AKAT6AALDH1A1 | |
| SCHEMBL7482004 | 0.84 | ALDH1A1 (0.46) | HDAC8ALDH1A1LMNAMMP2MMP9 | |
| SCHEMBL7472363 | 0.83 | L3MBTL1 (0.49) | HDAC8SMN1; SMN2RAB9AALDH1A1MMP2 | |
| SCHEMBL7472887 | 0.82 | ALDH1A1 (0.48) | NPC1SMN1; SMN2RAB9AALDH1A1LMNA | |
| SCHEMBL7471334 | 0.82 | SMN1; SMN2 (0.52) | HDAC8NPC1SMN1; SMN2RAB9AKAT6A | |
| SCHEMBL7482260 | 0.82 | KCNA3 (0.48) | NPC1SMN1; SMN2RAB9AALDH1A1MEN1 | |
| SCHEMBL7646518 | 0.81 | NR1H4 (0.43) | NPC1RAB9AMEN1KMT2AHDAC1 | |
| SCHEMBL7483118 | 0.79 | NR1H4 (0.44) | HDAC8SMN1; SMN2LMNAMMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |