Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8590384 | 0.99 | LMNA (0.45) | LMNAGAAALDH1A1HPGDSMN1; SMN2 | |
| Water SCHEMBL8743054 | 0.99 | LMNA (0.45) | LMNAGAAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7468186 | 0.94 | ALDH1A1 (0.44) | LMNAGAAALDH1A1HPGDPTPN11 | |
| SCHEMBL7467895 | 0.81 | PTPN11 (0.41) | PTPN11 | |
| Trifluoroacetic Acid SCHEMBL8590187 | 0.79 | PTPN11 (0.39) | PTPN11 | |
| SCHEMBL7466955 | 0.77 | PTPN11 (0.37) | LMNAALDH1A1PTPN11USP2TSHR | |
| SCHEMBL7477081 | 0.76 | GPR119 (0.49) | ALDH1A1USP2TSHR | |
| SCHEMBL7466247 | 0.75 | PTPN11 (0.39) | LMNAALDH1A1PTPN11USP2TSHR | |
| Trifluoroacetic Acid SCHEMBL8742909 | 0.75 | PTPN11 (0.35) | LMNASMN1; SMN2PTPN11TSHRTP53 | |
| SCHEMBL9221623 | 0.74 | ALDH1A1 (0.43) | LMNAGAAALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687251-B1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI SYNTHELABO (FR) | 2002-02-27 | — | — | EP | disclosed |
| WO-1995018105-A1 | 1,3-DIHYDROINDOL-2-ONE DERIVATIVES SUBSTITUTED IN POSITION 3 BY A NITROGEN GROUP AS VASOPRESSIN AND/OR OCYTOCINE AGONISTS AND/OR ANTAGONISTS | SANOFI (FR) | 1995-07-06 | — | — | WO | disclosed |