Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115703 | 0.88 | HTR1A (0.41) | SIGMAR1HTR1AKDM4ECYP1A2GAA | |
| Hydrochloric Acid SCHEMBL8115889 | 0.87 | HTR1A (0.40) | SIGMAR1HTR1AKDM4ECYP1A2GAA | |
| Citric Acid SCHEMBL7477509 | 0.87 | HTR1A (0.43) | SIGMAR1HTR1AKDM4ECYP1A2GAA | |
| SCHEMBL8418004 | 0.86 | HTR1A (0.48) | HTR1ADRD2 | |
| SCHEMBL8113668 | 0.80 | ALDH1A1 (0.47) | HTR1AKDM4E | |
| SCHEMBL8416539 | 0.79 | HTR2A (0.55) | SIGMAR1HTR1AKDM4EDRD2 | |
| SCHEMBL8416503 | 0.77 | HTR1A (0.61) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL8416472 | 0.77 | KDM4E (0.61) | HTR1AKDM4EDRD2 | |
| SCHEMBL8336244 | 0.75 | SIGMAR1 (0.52) | SIGMAR1HTR1AKDM4ECYP1A2GAA | |
| SCHEMBL7521159 | 0.74 | SIGMAR1 (0.66) | SIGMAR1HTR1AKDM4ECYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007522-B1 | 2- 4-[4-(4,5-DICHLORO-2-METHYLIMIDAZOL-1-YL)BUTYL]PIPERAZIN-1-YL -5-FLUOROPYRIMIDINE, ITS PREPARATION AND THERAPEUTIC USE | ESTEVE LABOR DR (ES) | 2002-11-20 | — | — | EP | claimed |
| US-6346620-B1 | DEHYDROHALOGEN WITH AMINATION IN THE PRESENCE OF POTASSIUM CARBONATE IN APROTIC SOLVENT | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2002-02-12 | — | — | US | claimed |
| US-6303608-B1 | 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-fluoropyrimidine, its preparation and its therapeutic use | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-10-16 | — | — | US | claimed |
| EP-1007522-A1 | 2- 4-[4-(4, 5-DICHLORO -2-METHYLIMIDAZOL-1-YL) BUTYL]-1-PIPERAZINYL -5-FLUOROPYRIMIDINE,PREPARATION AND THERAPEUTIC USE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2000-06-14 | — | — | EP | claimed |
| WO-1998055476-A1 | 2-{4-[4-(4,5-DICHLORO-2- METHYLIMIDAZOL-1-YL)BUTYL] -1-PIPERAZINYL}-5-FLUOROPYRIMIDINE, PREPARATION AND THERAPEUTIC USE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1998-12-10 | — | — | WO | claimed |
| EP-1007522-B1 | 2- 4-[4-(4,5-DICHLORO-2-METHYLIMIDAZOL-1-YL)BUTYL]PIPERAZIN-1-YL -5-FLUOROPYRIMIDINE, ITS PREPARATION AND THERAPEUTIC USE | ESTEVE LABOR DR (ES) | 2002-11-20 | — | — | EP | disclosed |
| EP-1007522-B1 | 2- 4-[4-(4,5-DICHLORO-2-METHYLIMIDAZOL-1-YL)BUTYL]PIPERAZIN-1-YL -5-FLUOROPYRIMIDINE, ITS PREPARATION AND THERAPEUTIC USE | ESTEVE LABOR DR (ES) | 2002-11-20 | — | — | EP | disclosed |
| EP-1007522-B1 | 2- 4-[4-(4,5-DICHLORO-2-METHYLIMIDAZOL-1-YL)BUTYL]PIPERAZIN-1-YL -5-FLUOROPYRIMIDINE, ITS PREPARATION AND THERAPEUTIC USE | ESTEVE LABOR DR (ES) | 2002-11-20 | — | — | EP | disclosed |
| CN-1094491-C | 2- {4- [4- (4, 5-dichloro-2-methylimidazol-1-yl) butyl ] -1-piperazinyl } -5-fluoropyrimidine, process for its preparation and its use | ESTEVE LABOR DR (ES) | 2002-11-20 | — | — | CN | disclosed |
| US-6346620-B1 | DEHYDROHALOGEN WITH AMINATION IN THE PRESENCE OF POTASSIUM CARBONATE IN APROTIC SOLVENT | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2002-02-12 | — | — | US | disclosed |
| US-6346620-B1 | DEHYDROHALOGEN WITH AMINATION IN THE PRESENCE OF POTASSIUM CARBONATE IN APROTIC SOLVENT | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2002-02-12 | — | — | US | disclosed |
| US-6346620-B1 | DEHYDROHALOGEN WITH AMINATION IN THE PRESENCE OF POTASSIUM CARBONATE IN APROTIC SOLVENT | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2002-02-12 | — | — | US | disclosed |
| US-6303608-B1 | 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-fluoropyrimidine, its preparation and its therapeutic use | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-10-16 | — | — | US | disclosed |
| CN-1261888-A | 2{4-[4-(4,5-dichloro-2-methylimidazol-1-yl) butyl]-1-piperazinyl}-5-fluoropyrimiding, preparation and therapeutic use | ESTEVE LABOR DR (ES) | 2000-08-02 | — | — | CN | disclosed |
| EP-1007522-A1 | 2- 4-[4-(4, 5-DICHLORO -2-METHYLIMIDAZOL-1-YL) BUTYL]-1-PIPERAZINYL -5-FLUOROPYRIMIDINE,PREPARATION AND THERAPEUTIC USE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2000-06-14 | — | — | EP | disclosed |
| EP-1007522-A1 | 2- 4-[4-(4, 5-DICHLORO -2-METHYLIMIDAZOL-1-YL) BUTYL]-1-PIPERAZINYL -5-FLUOROPYRIMIDINE,PREPARATION AND THERAPEUTIC USE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2000-06-14 | — | — | EP | disclosed |
| EP-1007522-A1 | 2- 4-[4-(4, 5-DICHLORO -2-METHYLIMIDAZOL-1-YL) BUTYL]-1-PIPERAZINYL -5-FLUOROPYRIMIDINE,PREPARATION AND THERAPEUTIC USE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2000-06-14 | — | — | EP | disclosed |
| WO-1998055476-A1 | 2-{4-[4-(4,5-DICHLORO-2- METHYLIMIDAZOL-1-YL)BUTYL] -1-PIPERAZINYL}-5-FLUOROPYRIMIDINE, PREPARATION AND THERAPEUTIC USE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998055476-A1 | 2-{4-[4-(4,5-DICHLORO-2- METHYLIMIDAZOL-1-YL)BUTYL] -1-PIPERAZINYL}-5-FLUOROPYRIMIDINE, PREPARATION AND THERAPEUTIC USE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998055476-A1 | 2-{4-[4-(4,5-DICHLORO-2- METHYLIMIDAZOL-1-YL)BUTYL] -1-PIPERAZINYL}-5-FLUOROPYRIMIDINE, PREPARATION AND THERAPEUTIC USE | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1998-12-10 | — | — | WO | disclosed |