Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839501 | 0.85 | HTR1A (0.48) | HTR1A | |
| SCHEMBL8340386 | 0.83 | HTR7 (0.57) | SIGMAR1DRD2HTR1A | |
| SCHEMBL8788615 | 0.79 | GRM2 (0.42) | SIGMAR1DRD2HTR1A | |
| SCHEMBL8336417 | 0.79 | HTR3E (0.53) | SIGMAR1HTR1A | |
| SCHEMBL8341291 | 0.79 | GRM2 (0.53) | DRD2 | |
| SCHEMBL8788970 | 0.78 | MCHR1 (0.48) | SIGMAR1DRD2HTR1A | |
| SCHEMBL9053834 | 0.75 | DRD2 (0.50) | SIGMAR1CYP1A2CYP2C9DRD2HTR1A | |
| SCHEMBL7474002 | 0.75 | SIGMAR1 (0.53) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL8337662 | 0.74 | PLK1 (0.51) | — | |
| SCHEMBL15748179 | 0.74 | HTR7 (0.55) | KDM4EDRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |