Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21806628 | 0.78 | CYP4F2 (0.41) | ALDH1A1TSHR | |
| SCHEMBL27342277 | 0.76 | GABRA1 (0.42) | SLC6A4SLC6A2SLC6A3LMNAALDH1A1 | |
| SCHEMBL12646286 | 0.76 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3HTR2ASMN1; SMN2 | |
| SCHEMBL681660 | 0.75 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3HTR2ASMN1; SMN2 | |
| SCHEMBL17428477 | 0.74 | TSHR (0.52) | SLC6A4SLC6A2SLC6A3HTR2ALMNA | |
| SCHEMBL5377770 | 0.74 | ALDH1A1 (0.34) | SLC6A4SLC6A2SLC6A3HTR2ASMN1; SMN2 | |
| SCHEMBL6141292 | 0.74 | L3MBTL1 (0.35) | ALDH1A1 | |
| SCHEMBL9769320 | 0.73 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3HTR2AKCNH2 | |
| SCHEMBL11727401 | 0.72 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3HTR2ASMN1; SMN2 | |
| SCHEMBL13407804 | 0.72 | SLC6A4 (0.70) | SLC6A4SLC6A2SLC6A3HTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |