Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385149 | 0.87 | RAB9A (0.49) | PTGER1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7381559 | 0.80 | PTGER1 (0.61) | PTGER1HPGDSMMP2MMP13ALDH1A1 | |
| SCHEMBL15602916 | 0.76 | PTGER1 (0.54) | PTGER1HPGDSMMP2MMP13ALDH1A1 | |
| SCHEMBL14124904 | 0.75 | PTGER1 (0.53) | PTGER1HPGDSMMP2MMP13ALDH1A1 | |
| SCHEMBL26319777 | 0.75 | MMP2 (0.52) | PTGER1HPGDSMMP2MMP13 | |
| SCHEMBL27924176 | 0.75 | MCL1 (0.60) | HPGDSMMP2MMP13ALDH1A1 | |
| SCHEMBL2526976 | 0.75 | ALDH1A1 (0.59) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL29506850 | 0.75 | RXRA (0.57) | PTGER1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL30929959 | 0.75 | RXRA (0.57) | PTGER1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7087561 | 0.74 | PTGER1 (0.52) | PTGER1MAPTMRGPRX4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019046-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1019046-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998048799-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |