Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759899 | 0.82 | ACACB (0.43) | ALDH1A1KDM4EACACBACACA | |
| SCHEMBL7471855 | 0.80 | HDAC3 (0.39) | APPOPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL16244844 | 0.75 | CCR1 (0.49) | APPOPRD1OPRK1KDM4ECHRM4 | |
| SCHEMBL8915729 | 0.74 | OPRM1 (0.53) | APPOPRD1OPRK1LMNAPOLB | |
| SCHEMBL9311071 | 0.74 | OPRM1 (0.57) | APPOPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL7425816 | 0.73 | SMN1; SMN2 (0.45) | OPRD1OPRK1L3MBTL1CHRM4LMNA | |
| SCHEMBL7478597 | 0.72 | MEN1 (0.48) | APPOPRD1OPRK1ALDH1A1KDM4E | |
| SCHEMBL7422101 | 0.70 | CHRM4 (0.45) | OPRD1OPRK1L3MBTL1CHRM4LMNA | |
| SCHEMBL9529108 | 0.70 | APP (0.59) | APPOPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL31096768 | 0.70 | APP (0.41) | APPOPRD1OPRK1ALDH1A1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244622-A1 | A PROCESS FOR PREPARING TRANS-2,4-DISUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY (US) | 2002-10-02 | — | — | EP | disclosed |
| EP-1244623-A1 | A PROCESS FOR PREPARING 4-SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001046143-A1 | A PROCESS FOR PREPARING TRANS-2,4-DISUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001046147-A1 | A PROCESS FOR PREPARING 4-SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |