Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.51 |
| ▸ | RXRB | P28702 | 3/20 | 0.51 |
| ▸ | RXRG | P48443 | 3/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLQ | O75417 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337724 | 0.87 | ALDH1A1 (0.53) | RXRARXRBRXRGNR1H2NR1H3 | |
| SCHEMBL7472612 | 0.86 | CES2 (0.44) | RXRARXRBRXRGNR1H2NR1H3 | |
| SCHEMBL8916995 | 0.83 | CFTR (0.46) | RXRANR1H2NR1H3CES2ALDH1A1 | |
| SCHEMBL17899450 | 0.81 | RXRA (0.72) | RXRARXRBRXRGNR1H2NR1H3 | |
| SCHEMBL3135089 | 0.80 | RXRA (0.53) | RXRARXRBRXRGCES2ALDH1A1 | |
| SCHEMBL3741058 | 0.78 | POLQ (0.61) | RXRARXRBRXRGCES2POLQ | |
| SCHEMBL30716953 | 0.78 | POLQ (0.61) | RXRARXRBRXRGCES2POLQ | |
| SCHEMBL30530542 | 0.78 | IDO1 (0.51) | RXRARXRBRXRGALDH1A1HPGD | |
| SCHEMBL512428 | 0.78 | IDO1 (0.51) | RXRARXRBRXRGALDH1A1HPGD | |
| SCHEMBL27905706 | 0.78 | RXRA (0.51) | RXRARXRBRXRGNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |