Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473981 | 0.89 | ALDH1A1 (0.46) | ALDH1A1KDM4E | |
| SCHEMBL7466818 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4ESMN1; SMN2TSHRNPSR1 | |
| SCHEMBL7471275 | 0.87 | SLC6A1 (0.55) | — | |
| Acetic Acid SCHEMBL7473986 | 0.86 | SLC6A1 (0.53) | — | |
| SCHEMBL8715371 | 0.81 | SLC6A1 (0.62) | — | |
| SCHEMBL8171926 | 0.80 | KDM4E (0.56) | ALDH1A1KDM4ESMN1; SMN2TSHRMAPK1 | |
| SCHEMBL8171924 | 0.80 | KDM4E (0.56) | ALDH1A1KDM4ESMN1; SMN2TSHRMAPK1 | |
| SCHEMBL9690362 | 0.80 | ALDH1A1 (0.57) | ALDH1A1KDM4ESMN1; SMN2TSHRMAPK1 | |
| SCHEMBL8934806 | 0.78 | SLC6A1 (0.53) | — | |
| SCHEMBL8720397 | 0.78 | KDM4E (0.54) | ALDH1A1KDM4ESMN1; SMN2TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851865-B1 | 12H-Dibenzo[d,g][1,3]dioxocine derivatives | NOVO NORDISK AS (DK) | 2002-07-17 | — | — | EP | disclosed |
| US-6017915-A | Heterocyclic compounds | NOVO NORDISK A/S (DK) | 2000-01-25 | — | — | US | disclosed |
| EP-0851865-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997011071-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1997-03-27 | — | — | WO | disclosed |