Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472371 | 0.88 | LTA4H (0.47) | LTA4HSIGMAR1HPGDNPSR1TBXA2R | |
| Hydrochloric Acid SCHEMBL7464493 | 0.87 | LTA4H (0.46) | LTA4HSIGMAR1HPGDNPSR1TBXA2R | |
| SCHEMBL7474386 | 0.87 | LTA4H (0.42) | LTA4HNPSR1DRD2HTR2ADRD3 | |
| SCHEMBL8204452 | 0.79 | SIGMAR1 (0.41) | SIGMAR1DRD2HTR2ADRD3CHRM3 | |
| SCHEMBL7603812 | 0.78 | LTA4H (0.46) | LTA4HSIGMAR1DRD2HTR2ADRD3 | |
| SCHEMBL7468711 | 0.77 | SIGMAR1 (0.46) | LTA4HSIGMAR1HRH1 | |
| Hydrochloric Acid SCHEMBL8181412 | 0.77 | LTA4H (0.46) | LTA4HSIGMAR1DRD2HTR2ADRD3 | |
| Oxalic Acid SCHEMBL8171907 | 0.77 | ACHE (0.40) | SIGMAR1DRD2HTR2ADRD3PPARG | |
| SCHEMBL7473583 | 0.76 | SIGMAR1 (0.43) | SIGMAR1CHRM3PPARGHRH1 | |
| SCHEMBL7463247 | 0.76 | ALDH1A1 (0.51) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851865-B1 | 12H-Dibenzo[d,g][1,3]dioxocine derivatives | NOVO NORDISK AS (DK) | 2002-07-17 | — | — | EP | disclosed |
| US-6017915-A | Heterocyclic compounds | NOVO NORDISK A/S (DK) | 2000-01-25 | — | — | US | disclosed |
| US-5972925-A | 1-(3-(2-CHLORO-12H-DIBENZO(D,G)(1,3,6)DIOXAZOCIN-12-YL)-1-PROP YL)-3-PIPERIDINECARBOXYLIC ACID, FOR EXAMPLE; TREATING NEUROGENIC PAIN (IN WHICH C-FIBERS PLAY A ROLE) OR INFLAMMATION SUCH AS MIGRAINE OR DIABETIC NEUROPATHY | NOVO NORDISK A/S (DK) | 1999-10-26 | — | — | US | disclosed |
| EP-0851865-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997011071-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1997-03-27 | — | — | WO | disclosed |