Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 11/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465897 | 0.88 | DRD2 (0.49) | NPC1RAB9AMEN1KMT2ADRD4 | |
| SCHEMBL7476441 | 0.81 | LMNA (0.64) | DRD4DRD2DRD3ALDH1A1SMN1; SMN2 | |
| SCHEMBL7470536 | 0.78 | KDM4E (0.58) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL7423903 | 0.74 | ALOX15 (0.60) | NPC1RAB9AMEN1POLBKMT2A | |
| SCHEMBL7478660 | 0.73 | DRD4 (0.63) | MEN1KMT2ADRD4DRD2DRD3 | |
| SCHEMBL7465842 | 0.72 | DRD4 (0.46) | MEN1KMT2ADRD4DRD2DRD3 | |
| SCHEMBL8216077 | 0.72 | DRD2 (0.59) | KMT2ADRD2ALDH1A1LMNA | |
| SCHEMBL17731134 | 0.72 | DRD4 (0.67) | NPC1DRD4DRD2DRD3ALDH1A1 | |
| SCHEMBL3893619 | 0.71 | SMN1; SMN2 (0.61) | MEN1POLBKMT2ADRD4DRD2 | |
| SCHEMBL3903652 | 0.71 | DRD4 (0.54) | MEN1KMT2ADRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |