Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476763 | 0.88 | NPC1 (0.54) | DRD2DRD3DRD4MEN1KMT2A | |
| SCHEMBL7476550 | 0.78 | DRD2 (0.55) | DRD2 | |
| SCHEMBL7963986 | 0.76 | DRD2 (0.62) | DRD2MCHR1DRD3ADRA1ACCR2 | |
| SCHEMBL7476648 | 0.75 | CACNA1G (0.59) | DRD2DRD3DRD4ADRA1AADRA2A | |
| SCHEMBL7470932 | 0.73 | HRH3 (0.49) | DRD2TP53MCHR1DRD4HRH3 | |
| SCHEMBL7474472 | 0.72 | S1PR1 (0.46) | DRD2MCHR1DRD4HRH3 | |
| SCHEMBL7957652 | 0.71 | DRD2 (0.55) | DRD2MCHR1DRD3DRD4ADRA1A | |
| SCHEMBL8001944 | 0.69 | DRD2 (0.65) | DRD2TP53DRD3CCR2MEN1 | |
| SCHEMBL8011291 | 0.69 | DRD2 (0.65) | DRD2TP53DRD3CCR2MEN1 | |
| SCHEMBL7470536 | 0.69 | KDM4E (0.58) | MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |