Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485803 | 0.89 | LIPE (0.35) | TRPM8LIPENPC1RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL7484862 | 0.88 | LIPE (0.35) | TRPM8LIPENPC1RAB9ATP53 | |
| SCHEMBL7482587 | 0.82 | GRIN2D (0.37) | TRPM8LIPENPC1RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL7479742 | 0.74 | LIPE (0.51) | TRPM8LIPENPC1RAB9AEED | |
| SCHEMBL7477612 | 0.72 | NAMPT (0.42) | SMN1; SMN2NAMPTHPGDCYP1A2CYP3A4 | |
| SCHEMBL7477903 | 0.70 | EED (0.54) | LIPENPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL7534680 | 0.69 | NAMPT (0.33) | SMN1; SMN2NAMPTGAAKDM4EALDH1A1 | |
| SCHEMBL7477144 | 0.69 | NISCH (0.31) | KMT2A | |
| Bromide SCHEMBL7480922 | 0.68 | NISCH (0.30) | — | |
| SCHEMBL7481285 | 0.68 | SLC6A2 (0.47) | EEDNAMPTGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | claimed |