Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485803 | 0.82 | LIPE (0.35) | NAMPTALDH1A1KDM4ESMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL7484862 | 0.81 | LIPE (0.35) | NAMPTALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL7490258 | 0.77 | KDM4E (0.41) | NAMPTALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL7476772 | 0.72 | TRPM8 (0.34) | NAMPTALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL7480722 | 0.67 | CYP19A1 (0.41) | CYP2C9CYP1A2CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL7484298 | 0.66 | NAMPT (0.36) | NAMPTALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| Bromide SCHEMBL7478970 | 0.66 | CYP19A1 (0.40) | CYP2C9CYP1A2CYP2D6CYP2C19DRD2 | |
| SCHEMBL7482587 | 0.66 | GRIN2D (0.37) | NAMPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL7481285 | 0.65 | SLC6A2 (0.47) | NAMPT | |
| SCHEMBL7482870 | 0.64 | ABHD6 (0.48) | NAMPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | claimed |