SCHEMBL8860233

SCHEMBL8860233

COc1ccc2c(c1)CC(=O)N2Nc1ccncc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 7/20 0.43
ALDH1A1 P00352 4/20 0.40
MAPT P10636 3/20 0.40
LMNA P02545 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MIF P14174 1/20 0.40
TYK2 P29597 2/20 0.39
JAK2 O60674 1/20 0.39
MEN1 O00255 1/20 0.39
HPGD P15428 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP11B1 P15538 1/20 0.39
CYP11B2 P19099 1/20 0.39
DRD2 P14416 1/20 0.38
DRD1 P21728 1/20 0.38
DRD5 P21918 1/20 0.38
DRD3 P35462 1/20 0.38
ERBB2 P04626 1/20 0.37
PRKACA P17612 1/20 0.37
RPS6KB1 P23443 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7476799 0.82 ALDH1A1 (0.51) CYP19A1ALDH1A1MAPTLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL8418434 0.81 ALDH1A1 (0.49) CYP19A1ALDH1A1MAPTLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL8418433 0.81 ALDH1A1 (0.49) CYP19A1ALDH1A1MAPTLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL7482266 0.80 ALDH1A1 (0.48) CYP19A1ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL8860183 0.76 CASP6 (0.51) CYP19A1MAPTHPGD
SCHEMBL8860253 0.75 CASP6 (0.38) CYP19A1ALDH1A1SMN1; SMN2MEN1HPGD
SCHEMBL7479666 0.73 APP (0.46) CYP19A1ALDH1A1MAPTLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL7485356 0.72 APP (0.45) CYP19A1ALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL7474190 0.71 ROCK2 (0.49) CYP19A1ALDH1A1MAPTTYK2JAK2
SCHEMBL578369 0.71 LMNA (0.60) ALDH1A1LMNAMEN1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5053511-A Analgesics; anticonvulsants; treatment for alzheimers disease HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1991-10-01 US claimed
US-5686626-A COGNITION ACTIVATORS HOECHST MARION ROUSSEL, INC. (US) 1997-11-11 US disclosed
US-5621116-A CHEMICAL INTERMEDIATES; MEMORY ENHANCERS FOR TREATMENT OF ALZHEIMER*S, ANALGESICS, ANTICONVULSANTS HOECHST MARION ROUSSEL, INC. (US) 1997-04-15 US disclosed
US-5464846-A Learning enhancement, Alzheimer's disease HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1995-11-07 US disclosed
EP-0415102-B1 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-ones, a process for their preparation and their use as medicaments HOECHST ROUSSEL PHARMA (US) 1995-02-01 EP disclosed
US-5179119-A Cognition activators; alzheimer*s disease HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1993-01-12 US disclosed
US-5053511-A Analgesics; anticonvulsants; treatment for alzheimers disease HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1991-10-01 US disclosed
EP-0415102-A1 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-ones, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1991-03-06 EP disclosed