Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4875167 | 0.77 | MAPT (0.46) | KDM4EALDH1A1GAANPC1MAPT | |
| SCHEMBL16263093 | 0.73 | NPC1 (0.53) | KDM4EALDH1A1GAANPC1RECQL | |
| SCHEMBL234452 | 0.71 | ACHE (0.47) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4912670 | 0.69 | ALDH1A1 (0.45) | KDM4EALDH1A1GAANPC1NPSR1 | |
| SCHEMBL8090146 | 0.68 | ALDH1A1 (0.38) | KDM4EALDH1A1NPC1MAPTLMNA | |
| SCHEMBL4875157 | 0.68 | RAB9A (0.46) | KDM4EALDH1A1NPC1MAPTLMNA | |
| SCHEMBL29133411 | 0.68 | DHODH (0.46) | KDM4EALDH1A1NPC1MAPTLMNA | |
| SCHEMBL439225 | 0.68 | KDM4E (0.49) | KDM4EALDH1A1GAANPC1RECQL | |
| SCHEMBL578047 | 0.68 | KDM4E (0.47) | KDM4EALDH1A1GAANPC1RECQL | |
| SCHEMBL8087264 | 0.67 | CYP2C9 (0.53) | KDM4EALDH1A1NPC1RECQLNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |