Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.57 |
| ▸ | MMP9 | P14780 | 15/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.53 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478205 | 0.88 | MAPT (0.72) | MMP2MMP9MAPTMMP13MMP8 | |
| SCHEMBL7474147 | 0.85 | MMP2 (0.64) | MMP2MMP9MAPTMMP13MMP8 | |
| SCHEMBL7483991 | 0.80 | MAPT (0.73) | MMP2MMP9MAPTMMP13MMP8 | |
| SCHEMBL7480990 | 0.76 | MMP2 (0.58) | MMP2MMP9MAPTMMP13MMP8 | |
| SCHEMBL19212406 | 0.76 | ADRB1 (0.69) | MAPTNPY1RADRB1 | |
| SCHEMBL11074672 | 0.74 | ADRB1 (0.76) | MAPTADRB1 | |
| SCHEMBL8555925 | 0.73 | MMP8 (0.62) | MMP2MMP9MMP13MMP8 | |
| SCHEMBL14117695 | 0.73 | SCN9A (0.61) | MAPTMMP13ADRB1ADAM17ADAMTS5 | |
| SCHEMBL7475919 | 0.72 | MMP2 (0.87) | MMP2MMP9MAPTMMP13MMP8 | |
| SCHEMBL7484264 | 0.72 | MMP8 (0.59) | MMP2MMP9MMP13MMP8ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |