Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | MMP2 | P08253 | 18/20 | 0.59 |
| ▸ | MMP9 | P14780 | 18/20 | 0.59 |
| ▸ | MMP13 | P45452 | 3/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477228 | 0.88 | MMP2 (0.57) | MAPTMMP2MMP9MMP13MMP8 | |
| SCHEMBL7474147 | 0.87 | MMP2 (0.64) | MAPTMMP2MMP9MMP13MMP8 | |
| SCHEMBL7480990 | 0.81 | MMP2 (0.58) | MAPTMMP2MMP9MMP13MMP8 | |
| SCHEMBL7475919 | 0.79 | MMP2 (0.87) | MAPTMMP2MMP9MMP13MMP8 | |
| SCHEMBL6441647 | 0.78 | MMP2 (0.62) | MMP2MMP9MMP13MMP8 | |
| SCHEMBL4664602 | 0.77 | MMP2 (0.72) | MAPTMMP2MMP9MMP13MMP8 | |
| SCHEMBL8555925 | 0.75 | MMP8 (0.62) | MMP2MMP9MMP13MMP8 | |
| SCHEMBL4664591 | 0.75 | MMP2 (0.69) | MAPTMMP2MMP9MMP13MMP8 | |
| SCHEMBL6153220 | 0.74 | ALDH1A1 (0.66) | MAPT | |
| SCHEMBL7484264 | 0.73 | MMP8 (0.59) | MMP2MMP9MMP13MMP8ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |