Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473758 | 0.86 | ALDH1A1 (0.54) | MAPTALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL7471841 | 0.86 | MAPK14 (0.44) | MAPTGAAALDH1A1HTTMITF | |
| SCHEMBL7466640 | 0.83 | LMNA (0.59) | KDM4ECYP2C9MAPTGAAALDH1A1 | |
| SCHEMBL7470913 | 0.83 | HTT (0.41) | KDM4ESRD5A2MAPTGAAALDH1A1 | |
| SCHEMBL7471112 | 0.83 | ALDH1A1 (0.49) | KDM4ECYP2C9MAPTGAAALDH1A1 | |
| SCHEMBL7475152 | 0.82 | MAPK14 (0.44) | KDM4EMAPTGAAALDH1A1HTT | |
| SCHEMBL7471362 | 0.81 | LTA4H (0.40) | ALDH1A1HTTSMN1; SMN2MAPK14 | |
| SCHEMBL7476225 | 0.80 | CYP11B1 (0.41) | MAPTHTTLMNAHSD17B10 | |
| SCHEMBL7473148 | 0.79 | MAPK14 (0.44) | MAPTGAAALDH1A1POLBLMNA | |
| SCHEMBL7474779 | 0.79 | ALDH1A1 (0.45) | CYP2C9SRD5A2MAPTALDH1A1GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |