Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476794 | 0.91 | HSD17B10 (0.41) | HTTHSD17B10ALDH1A1KDM4EHPGD | |
| SCHEMBL7471841 | 0.84 | MAPK14 (0.44) | HTTALDH1A1LMNAMAPTPOLB | |
| SCHEMBL11813166 | 0.84 | PDE4A (0.42) | ALDH1A1KDM4EHPGDGLASRD5A2 | |
| SCHEMBL7476225 | 0.83 | CYP11B1 (0.41) | HTTHSD17B10LMNAMAPTTSHR | |
| SCHEMBL7477253 | 0.83 | KDM4E (0.49) | HTTHSD17B10ALDH1A1KDM4ESRD5A2 | |
| SCHEMBL7470675 | 0.83 | HTT (0.41) | HTTHSD17B10ALDH1A1HPGDGLA | |
| SCHEMBL7473758 | 0.82 | ALDH1A1 (0.54) | HTTALDH1A1LMNAMAPTPOLB | |
| SCHEMBL7475152 | 0.81 | MAPK14 (0.44) | HTTHSD17B10ALDH1A1KDM4EHPGD | |
| SCHEMBL7471112 | 0.79 | ALDH1A1 (0.49) | HTTALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL7466640 | 0.79 | LMNA (0.59) | HTTALDH1A1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |