Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | RPA1 | P27694 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 5/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060155 | 0.86 | DHODH (0.47) | MAP2K4MAPK1MAPK6CA12ALPL | |
| SCHEMBL5069948 | 0.85 | ALDH1A1 (0.49) | MAP2K4MAPK1MAPK6ALPLDHODH | |
| SCHEMBL2487720 | 0.84 | SIRT1 (0.42) | MAP2K4MAPK1ALPLDHODHALDH1A1 | |
| SCHEMBL28738905 | 0.81 | KIF11 (0.43) | MAP2K4MAPK1MAPK6CA12ALPL | |
| SCHEMBL7483303 | 0.79 | KDM4E (0.55) | MAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5762375 | 0.78 | PBRM1 (0.44) | MAP2K4MAPK1MAPK6CA12ALPL | |
| SCHEMBL15779364 | 0.77 | MAP2K4 (0.45) | MAP2K4MAPK1MAPK6CA12ALPL | |
| SCHEMBL7476427 | 0.77 | ALOX5 (0.47) | MAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7478095 | 0.77 | MAPK14 (0.42) | MAPK1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7472841 | 0.77 | HSD17B14 (0.44) | MAP2K4MAPK1MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |