Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416015 | 0.87 | KMT2A (0.34) | HRH3POLBKMT2ALMNAMEN1 | |
| SCHEMBL7411562 | 0.86 | KMT2A (0.35) | HRH3KMT2ALMNA | |
| SCHEMBL7411225 | 0.86 | KMT2A (0.35) | HRH3KMT2ALMNA | |
| SCHEMBL8506871 | 0.83 | ALDH1A1 (0.37) | KMT2ALMNA | |
| SCHEMBL8506868 | 0.83 | ALDH1A1 (0.37) | KMT2ALMNA | |
| SCHEMBL7478135 | 0.83 | SCN9A (0.33) | HRH3 | |
| SCHEMBL7479313 | 0.82 | HRH3 (0.31) | HRH3 | |
| SCHEMBL7412567 | 0.81 | HRH3 (0.36) | HRH3KMT2ALMNAMEN1GPR119 | |
| SCHEMBL7411612 | 0.80 | CHRNB2 (0.41) | GPR119 | |
| SCHEMBL7413845 | 0.80 | KMT2A (0.40) | HRH3KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6403575-B1 | ANTI-INFLAMMATORIES | ABBOTT LABORATORIES | 2002-06-11 | — | — | US | disclosed |
| US-6133253-A | NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |