Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410349 | 0.85 | CHRNB1 (0.38) | CHRNB2CHRNA4CYP11B2CHRNB4CHRNA3 | |
| SCHEMBL7407010 | 0.84 | CHRNB2 (0.39) | CHRNB2CHRNA4GAA | |
| SCHEMBL7407935 | 0.84 | ABHD6 (0.35) | CYP11B2GPR119ADORA2B | |
| SCHEMBL6583035 | 0.84 | CHRNB2 (0.39) | CHRNB2CHRNA4GAA | |
| SCHEMBL8507388 | 0.81 | CHRNB2 (0.39) | CHRNB2CHRNA4GAA | |
| SCHEMBL8507386 | 0.81 | CHRNB2 (0.39) | CHRNB2CHRNA4GAA | |
| SCHEMBL7416527 | 0.81 | PTGS2 (0.33) | GPR119 | |
| SCHEMBL7478780 | 0.80 | HRH3 (0.32) | GPR119 | |
| SCHEMBL7670153 | 0.76 | CHRNB1 (0.47) | CHRNB2CYP11B2CHRNB4CHRNA3 | |
| SCHEMBL7416015 | 0.75 | KMT2A (0.34) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |