Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469964 | 0.88 | NPC1 (0.42) | LMNAKDM4EALDH1A1RAB9AKCNE1 | |
| SCHEMBL7472708 | 0.80 | MAPT (0.48) | LMNAALDH1A1GAAHTTRAB9A | |
| SCHEMBL7477380 | 0.79 | TRPV1 (0.42) | KDM4EALDH1A1RAB9ATRPV1KCNE1 | |
| SCHEMBL7471017 | 0.79 | MAPK1 (0.44) | LMNAKDM4EALDH1A1HTTMAPK1 | |
| SCHEMBL14256398 | 0.78 | KCNE1 (0.45) | POLBTRPV1KCNE1KCNQ1MAPT | |
| SCHEMBL7477208 | 0.78 | HSD17B10 (0.41) | ALDH1A1GAAHTTTRPV1TSHR | |
| SCHEMBL7470001 | 0.78 | KCNE1 (0.42) | TRPV1KCNE1KCNQ1 | |
| SCHEMBL7464041 | 0.77 | SMN1; SMN2 (0.46) | GAATRPV1KCNE1KCNQ1KMT2A | |
| SCHEMBL4621868 | 0.76 | KMT2A (0.42) | ALDH1A1HTTRAB9ATRPV1KCNE1 | |
| SCHEMBL7474635 | 0.76 | KCNE1 (0.48) | TRPV1KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |