Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477380 | 0.84 | TRPV1 (0.42) | ALDH1A1NPC1RAB9AKDM4ERXFP1 | |
| SCHEMBL7469964 | 0.83 | NPC1 (0.42) | LMNAALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7470001 | 0.82 | KCNE1 (0.42) | — | |
| SCHEMBL7464041 | 0.82 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7478341 | 0.79 | ALDH1A1 (0.48) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7477267 | 0.79 | ALDH1A1 (0.43) | MAPK1HTTLMNAMEN1KMT2A | |
| SCHEMBL7479262 | 0.79 | LMNA (0.41) | MAPK1HTTLMNAKMT2AALDH1A1 | |
| SCHEMBL7468807 | 0.78 | KCNE1 (0.40) | MEN1KMT2A | |
| SCHEMBL7468844 | 0.78 | TRPV1 (0.42) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7472708 | 0.78 | MAPT (0.48) | HTTLMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |