Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468731 | 0.92 | ALDH1A1 (0.39) | ALDH1A1ALOX15CYP3A4MEN1KMT2A | |
| SCHEMBL7467207 | 0.81 | AKR1B1 (0.33) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7473896 | 0.80 | KMT2A (0.34) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7477508 | 0.75 | ALOX15 (0.39) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8525004 | 0.75 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL7473827 | 0.75 | KCNA5 (0.38) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL8481164 | 0.74 | MAPT (0.38) | ALDH1A1KMT2ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL7470193 | 0.73 | KDM4E (0.38) | ALDH1A1CYP3A4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7471976 | 0.73 | KCNE1 (0.33) | CYP3A4MEN1KMT2A | |
| SCHEMBL7473128 | 0.73 | KCNE1 (0.33) | CYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |