SCHEMBL7479797

SCHEMBL7479797

CN(C)C(=O)Oc1ccc(Br)c2c1CN(Nc1ccncc1)CC2

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.40
NCEH1 Q6PIU2 6/20 0.38
ACHE P22303 3/20 0.35
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
HDAC1 Q13547 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7476937 0.83 CYP19A1 (0.42) PKMHDAC1HDAC6
SCHEMBL7479802 0.82 HDAC1 (0.31) HDAC1HDAC6
SCHEMBL7480200 0.82 ACHE (0.41) ACHEMAOAMAOB
SCHEMBL7480336 0.80 KDM4E (0.44) NCEH1ACHE
Hydrochloric Acid SCHEMBL7490200 0.79 KDM4E (0.43) NCEH1ACHE
SCHEMBL7484619 0.78 BCHE (0.38) PKMACHEMAOAMAOB
Fumaric Acid SCHEMBL7480472 0.77 SLC6A2 (0.39) ACHEMAOAMAOB
Fumaric Acid SCHEMBL7480474 0.77 SLC6A2 (0.39) ACHEMAOAMAOB
SCHEMBL7477892 0.77 FAAH (0.32)
SCHEMBL7483738 0.76 ACHE (0.40) NCEH1ACHEMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP claimed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP claimed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO claimed
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed