SCHEMBL7476937

SCHEMBL7476937

COc1ccc(Br)c2c1CN(Nc1ccncc1)CC2

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 4/20 0.42
HDAC1 Q13547 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
CYP1A2 P05177 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
DRD2 P14416 2/20 0.33
DRD1 P21728 2/20 0.33
ALDH1A1 P00352 1/20 0.33
PKM P14618 1/20 0.33
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
RAB9A P51151 1/20 0.32
RECQL P46063 1/20 0.32
BUB1 O43683 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7487024 0.85 ALDH1A1 (0.38) MEN1KMT2AALDH1A1PKM
SCHEMBL7477780 0.85 DRD1 (0.36) CYP19A1MEN1KMT2ADRD2DRD1
Hydrochloric Acid SCHEMBL7480606 0.84 DRD1 (0.36) CYP19A1MEN1KMT2ADRD2DRD1
SCHEMBL7479797 0.83 PKM (0.40) HDAC1HDAC6PKM
SCHEMBL7477892 0.81 FAAH (0.32)
SCHEMBL7482205 0.79 DRD2 (0.46) CYP19A1DRD2DRD1
SCHEMBL7478156 0.78 CHRNA7 (0.42) KDM4EMEN1KMT2AALDH1A1LMNA
SCHEMBL7479802 0.78 HDAC1 (0.31) HDAC1HDAC6
Hydrochloric Acid SCHEMBL7481922 0.78 CYP19A1 (0.44) CYP19A1HDAC1HDAC6DRD2DRD1
SCHEMBL7478121 0.77 DRD1 (0.44) CYP1A2KDM4EMEN1KMT2ADRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP claimed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP claimed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO claimed
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed