Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 9/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7480474 | 1.00 | SLC6A2 (0.39) | SLC6A2ACHEMAOAMAOBBCHE | |
| SCHEMBL7480200 | 0.94 | ACHE (0.41) | ACHEMAOAMAOBBCHEDRD2 | |
| Fumaric Acid SCHEMBL7477761 | 0.85 | BCHE (0.39) | SLC6A2ACHEMAOAMAOBBCHE | |
| Fumaric Acid SCHEMBL7477756 | 0.85 | BCHE (0.39) | SLC6A2ACHEMAOAMAOBBCHE | |
| SCHEMBL7483738 | 0.85 | ACHE (0.40) | ACHEMAOAMAOBBCHEKDM4E | |
| SCHEMBL7484619 | 0.78 | BCHE (0.38) | ACHEMAOAMAOBBCHEDRD2 | |
| SCHEMBL7482205 | 0.78 | DRD2 (0.46) | DRD2LIPE | |
| SCHEMBL7481472 | 0.77 | GRIN2D (0.34) | DRD2KDM4ELIPE | |
| SCHEMBL7479797 | 0.77 | PKM (0.40) | ACHEMAOAMAOB | |
| SCHEMBL7482870 | 0.76 | ABHD6 (0.48) | ACHEBCHELIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | disclosed |