SCHEMBL7480314

SCHEMBL7480314

COc1ccc2c(c1F)CN(Nc1ccncc1)C2

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
ACACB O00763 1/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
PKM P14618 1/20 0.34
CHEK1 O14757 1/20 0.33
RECQL P46063 1/20 0.33
BUB1 O43683 1/20 0.32
FGFR1 P11362 1/20 0.32
FGFR4 P22455 1/20 0.32
CYP3A4 P08684 2/20 0.32
CYP11B1 P15538 2/20 0.32
CYP11B2 P19099 2/20 0.32
KCNMA1 Q12791 1/20 0.32
CYP17A1 P05093 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
KDM4C Q9H3R0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7480188 0.82 KCNH2 (0.35) PKM
Hydrochloric Acid SCHEMBL7481921 0.81 KCNH2 (0.34) ALDH1A1PKM
SCHEMBL7480365 0.81 CYP19A1 (0.44) ALDH1A1SMN1; SMN2
SCHEMBL7477144 0.80 NISCH (0.31) MEN1KMT2A
Bromide SCHEMBL7480922 0.78 NISCH (0.30)
SCHEMBL7478752 0.76 KCNMA1 (0.39) ALDH1A1MEN1KMT2APKMRECQL
Hydrochloric Acid SCHEMBL7483308 0.75 KCNMA1 (0.38) ALDH1A1MEN1KMT2APKMRECQL
SCHEMBL7487024 0.74 ALDH1A1 (0.38) ALDH1A1MEN1KMT2APKMKCNMA1
SCHEMBL7478121 0.73 DRD1 (0.44) ALDH1A1MEN1KMT2APKMCYP3A4
Hydrochloric Acid SCHEMBL7479742 0.73 LIPE (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP claimed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP claimed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO claimed
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed