Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480445 | 1.00 | MAOA (0.42) | MAOAMAOBTTRHTR2AHTR2C | |
| SCHEMBL10673028 | 0.81 | GABRA1 (0.51) | MAOBTTRGABRA1GABRG2GABRB3 | |
| SCHEMBL10673014 | 0.81 | GABRA1 (0.51) | MAOBTTRGABRA1GABRG2GABRB3 | |
| SCHEMBL9869836 | 0.78 | PTGS1 (0.39) | HTR2AHTR2CKCNH2NFE2L2 | |
| SCHEMBL19926446 | 0.78 | NFE2L2 (0.35) | NFE2L2 | |
| SCHEMBL9651833 | 0.78 | PTGS1 (0.39) | HTR2AHTR2CKCNH2NFE2L2 | |
| SCHEMBL19926448 | 0.78 | NFE2L2 (0.35) | NFE2L2 | |
| SCHEMBL11350303 | 0.78 | ALDH1A1 (0.38) | NFE2L2 | |
| SCHEMBL7016426 | 0.75 | APP (0.39) | MAOBKCNH2NFE2L2 | |
| SCHEMBL7016433 | 0.75 | APP (0.39) | MAOBKCNH2NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1038873-B1 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | SERVIER LAB (FR) | 2002-05-02 | — | — | EP | disclosed |
| US-6153640-A | FOR TREATING DEPRESSION, PANIC ATTACKS, OBSESSIVE-COMPULSIVE DISORDERS, PHOBIAS, IMPULSIVE DISORDERS, DRUG ABUSE OR ANXIETY | ADIR ET COMPAGNIE (FR) | 2000-11-28 | — | — | US | disclosed |
| EP-1038873-A2 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | ADIR ET COMPAGNIE (FR) | 2000-09-27 | — | — | EP | disclosed |