Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483795 | 0.94 | MEN1 (0.65) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL7483978 | 0.88 | ABL1 (0.62) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL7488953 | 0.85 | KMT2A (0.57) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL7484054 | 0.83 | LMNA (0.61) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL7479597 | 0.83 | GLS (0.55) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL7423143 | 0.81 | MEN1 (0.62) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL7483438 | 0.80 | RAB9A (0.54) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL7483430 | 0.77 | RAB9A (0.51) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL28451175 | 0.77 | ABL1 (0.67) | MEN1KMT2AGAALMNAMAPT | |
| SCHEMBL3612969 | 0.76 | SMN1; SMN2 (0.76) | MEN1KMT2AGAALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |