Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.58 |
| ▸ | MMP9 | P14780 | 12/20 | 0.58 |
| ▸ | MMP3 | P08254 | 10/20 | 0.58 |
| ▸ | MMP2 | P08253 | 8/20 | 0.58 |
| ▸ | MMP8 | P22894 | 3/20 | 0.58 |
| ▸ | MMP7 | P09237 | 5/20 | 0.52 |
| ▸ | MMP13 | P45452 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | MMP15 | P51511 | 1/20 | 0.43 |
| ▸ | MMP16 | P51512 | 1/20 | 0.43 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483182 | 0.81 | MMP1 (0.79) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL7661343 | 0.78 | MMP1 (0.48) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL7480347 | 0.76 | MMP2 (0.81) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL7480352 | 0.76 | MMP2 (0.81) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL4312415 | 0.73 | MMP1 (1.00) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL7479388 | 0.73 | MMP1 (0.75) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL7428159 | 0.72 | MMP1 (0.80) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL7078092 | 0.71 | MMP1 (0.62) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL5639168 | 0.71 | MMP1 (0.61) | MMP1MMP9MMP3MMP2MMP8 | |
| SCHEMBL5636276 | 0.69 | MMP1 (0.73) | MMP1MMP9MMP3MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923561-B1 | HETEROCYCLIC METALLOPROTEASE INHIBITORS | PROCTER & GAMBLE (US) | 2002-10-23 | — | — | EP | disclosed |
| US-6399598-B1 | ORAL DISEASES; RHEUMATIC DISEASES; OSTEOPOROSIS | THE PROCTER & GAMBLE COMPANY | 2002-06-04 | — | — | US | disclosed |
| US-6121258-A | FOR TREATMENT OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS, SKIN DISORDERS, OCULAR DISORDERS, INFLAMMATION, GUM DISEASE | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-19 | — | — | US | disclosed |