SCHEMBL7481575

SCHEMBL7481575

CN1CCN(CCc2nc3c(N)cccc3[nH]2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 2/20 0.47
CHEK1 O14757 1/20 0.46
HTR3A P46098 2/20 0.46
DRD4 P21917 2/20 0.44
CHRNA7 P36544 1/20 0.43
HTR2A P28223 1/20 0.41
HTR2C P28335 1/20 0.41
HTR2B P41595 1/20 0.41
PARP1 P09874 2/20 0.41
HRH4 Q9H3N8 3/20 0.40
MEN1 O00255 1/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
PRKD3 O94806 1/20 0.39
PIM1 P11309 1/20 0.39
SRC P12931 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7474439 0.88 HTR6 (0.48) HTR6CHEK1HTR3ADRD4PARP1
SCHEMBL7484204 0.79 DRD4 (0.45) HTR6DRD4CHRNA7HRH4GAA
SCHEMBL30117400 0.78 DRD4 (0.67) DRD4CHRNA7POLBLMNATSHR
SCHEMBL7964155 0.77 CHEK1 (0.58) CHEK1PARP1MEN1POLBGAA
SCHEMBL6118505 0.75 HTR3A (0.54) HTR6HTR3APARP1HRH4MEN1
SCHEMBL7483052 0.75 HTT (0.58) CHEK1DRD4PARP1MEN1POLB
SCHEMBL7479734 0.74 HTT (0.61) CHEK1DRD4PARP1MEN1POLB
SCHEMBL8599171 0.74 CHEK1 (0.61) HTR6CHEK1PARP1MEN1POLB
SCHEMBL7967546 0.73 CHEK1 (0.51) HTR6CHEK1HTR2AHTR2CHTR2B
SCHEMBL6994637 0.73 CHEK1 (0.56) HTR6CHEK1PARP1MEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed
EP-1012164-A1 SERINE PROTEASE INHIBITORS Akzo Nobel N.V. (NL) 2000-06-28 EP disclosed
EP-0946519-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-06 EP disclosed
WO-1998024771-A1 BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-11 WO disclosed
WO-1997031939-A1 SERINE PROTEASE INHIBITORS AKZO NOBEL N.V. (NL) 1997-09-04 WO disclosed