SCHEMBL7484158

SCHEMBL7484158

CCCCOc1ccc(OC(=O)CCC)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL9 O00512 1/20 0.58
CTNNB1 P35222 1/20 0.58
ESR1 P03372 1/20 0.53
LMNA P02545 2/20 0.53
ALDH1A1 P00352 1/20 0.53
MAPT P10636 1/20 0.53
HTT P42858 1/20 0.53
KMT2A Q03164 1/20 0.53
HSD17B10 Q99714 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
TP53 P04637 1/20 0.53
TSHR P16473 1/20 0.53
NPC1 O15118 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
PLA2G4B P0C869 1/20 0.51
NFKB1 P19838 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10432965 0.95 TP53 (0.61) LMNATP53TSHRNPC1CYP1A2
SCHEMBL27524018 0.93 BCL9 (0.58) BCL9CTNNB1ESR1LMNAALDH1A1
SCHEMBL11023644 0.88 BCL9 (0.70) BCL9CTNNB1ESR1LMNAALDH1A1
SCHEMBL8612394 0.88 L3MBTL1 (0.57) ESR1LMNAKMT2AL3MBTL1TP53
SCHEMBL8921620 0.88 TP53 (0.61) ESR1LMNAKMT2ATP53TSHR
SCHEMBL27486854 0.88 TP53 (0.61) ESR1LMNAKMT2ATP53TSHR
SCHEMBL20703605 0.87 BCL9 (0.60) BCL9CTNNB1ESR1LMNAALDH1A1
SCHEMBL2705415 0.87 ESR1 (0.59) ESR1LMNAHTTKMT2ATP53
SCHEMBL11201899 0.87 NPC1 (0.69) LMNAMAPTKMT2ATP53TSHR
SCHEMBL9787771 0.86 THRA (0.54) BCL9CTNNB1ESR1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111020188-B Extracting agent and preparation method and application thereof 厦门稀土材料研究所 2021-09-14 CN disclosed
CN-111020188-A Extracting agent and preparation method and application thereof 厦门稀土材料研究所 2020-04-17 CN disclosed
US-6472396-B1 Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds ROCHE DIAGNOSTICS GMBH (DE) 2002-10-29 US disclosed
EP-0869947-B1 BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS ROCHE DIAGNOSTICS GMBH (DE) 2002-10-23 EP disclosed
US-6110924-A MATRIX METALLOPROTEASE INHIBITORS ROCHE DIAGNOSTICS GMBH (DE) 2000-08-29 US disclosed
EP-0869947-A1 NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1998-10-14 EP disclosed
WO-1997023465-A1 NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS BOEHRINGER MANNHEIM GMBH (DE) 1997-07-03 WO disclosed