Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 4/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479785 | 0.71 | POLB (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL27480645 | 0.69 | MEN1 (0.44) | MEN1KMT2AMAPTNR3C2LMNA | |
| SCHEMBL7484594 | 0.68 | RAB9A (0.53) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL27566867 | 0.61 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL4176732 | 0.59 | HTR1E (0.51) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL22188704 | 0.59 | HTR1E (0.51) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL2256136 | 0.58 | KDR (0.72) | — | |
| SCHEMBL8779422 | 0.57 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL14962091 | 0.57 | SLC6A2 (0.41) | — | |
| SCHEMBL11090182 | 0.57 | CA1 (0.37) | SMN1; SMN2MEN1KMT2ATP53GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |