Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 11/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.47 |
| ▸ | HTR3B | O95264 | 5/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443724 | 0.87 | HTR3A (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7434788 | 0.85 | HTR3A (0.52) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7432574 | 0.83 | HTR3A (0.60) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7430512 | 0.82 | HTR3E (0.56) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7444191 | 0.76 | HTR3E (0.45) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7430595 | 0.73 | HTR3A (0.67) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7437202 | 0.71 | ALDH1A1 (0.62) | EGFRALDH1A1KDM4EGAAHPGD | |
| SCHEMBL6672250 | 0.70 | HTR3E (0.50) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL29701 | 0.70 | ALDH1A1 (0.59) | EGFRALDH1A1KDM4E | |
| SCHEMBL984736 | 0.69 | EGFR (0.65) | EGFRALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248684-A | CERTAIN 2-OXO-QUINOLINE CARBOXYLATES OR CORRESPONDING CARBOXAMIDES USEFUL AS ANTI-EMETICS AND SUPPRESSANTS OF MIGRAINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0458636-A1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1991-11-27 | — | — | EP | disclosed |