Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.56 |
| ▸ | HTR3B | O95264 | 5/20 | 0.56 |
| ▸ | HTR3A | P46098 | 5/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432574 | 0.97 | HTR3A (0.60) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7434788 | 0.93 | HTR3A (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7484945 | 0.82 | HTR3A (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7443724 | 0.80 | HTR3A (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29280449 | 0.74 | MEN1 (0.74) | MEN1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL7439911 | 0.74 | HTR3A (0.68) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7438581 | 0.74 | HTR3E (0.85) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9680491 | 0.73 | HTR3A (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7435237 | 0.73 | HTR3A (0.78) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6126717 | 0.73 | HTT (0.74) | MEN1KMT2AKDM4EMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248684-A | CERTAIN 2-OXO-QUINOLINE CARBOXYLATES OR CORRESPONDING CARBOXAMIDES USEFUL AS ANTI-EMETICS AND SUPPRESSANTS OF MIGRAINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0458636-A1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1991-11-27 | — | — | EP | disclosed |