Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 6/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.41 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.38 |
| ▸ | CCNH | P51946 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494616 | 0.90 | CDK7 (0.44) | CDK9CDK2CDK7CDK13CDK12 | |
| SCHEMBL7491247 | 0.89 | ADORA2A (0.41) | CDK9CDK2CDK7CDK13CDK12 | |
| SCHEMBL7490786 | 0.86 | PRKAB2 (0.37) | CDK9CDK2CDK7CDK13CDK12 | |
| SCHEMBL30363677 | 0.75 | PDE10A (0.34) | CDK2PDE10ACCNA1CCNA2CHEK1 | |
| SCHEMBL7847802 | 0.75 | CDK9 (0.52) | CDK9CDK2CDK7CDK13CDK12 | |
| SCHEMBL7484447 | 0.74 | KCNN3 (0.43) | CDK2ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL7493929 | 0.73 | PDE10A (0.40) | CDK9CDK2CDK7CCNT1CCNH | |
| SCHEMBL5421748 | 0.72 | PDE10A (0.42) | CDK9CDK2CDK7CCNT1CCNH | |
| SCHEMBL5768681 | 0.72 | NOS2 (0.40) | CDK9CDK2CDK7CDK13CDK12 | |
| SCHEMBL7845174 | 0.70 | CDK7 (0.54) | CDK9CDK2CDK7CDK13CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915093-B1 | AMIDE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-11-27 | — | — | EP | disclosed |
| US-6166016-A | Amide derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0915093-A1 | AMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-05-12 | — | — | EP | disclosed |