Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 8/20 | 0.35 |
| ▸ | F7 | P08709 | 8/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL748554 | 0.89 | LPAR1 (0.36) | NR1I2LMNAADRA2ACYP2D6ACHE | |
| SCHEMBL745473 | 0.88 | KMT2A (0.44) | SIGMAR1MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL748724 | 0.87 | F10 (0.40) | SIGMAR1MEN1KMT2AF10F7 | |
| SCHEMBL751838 | 0.86 | ACHE (0.43) | NR1I2LMNAADRA2ACYP2D6ACHE | |
| SCHEMBL748461 | 0.85 | ESRRG (0.46) | LMNAHDAC1HDAC6MEN1KMT2A | |
| SCHEMBL747130 | 0.84 | SLC13A5 (0.37) | LMNAHDAC1HDAC6MEN1KMT2A | |
| SCHEMBL747114 | 0.84 | C5AR1 (0.41) | LMNAMEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL746610 | 0.84 | TP53 (0.42) | LMNAMEN1KMT2AF10F7 | |
| SCHEMBL748563 | 0.83 | MBTPS1 (0.39) | HDAC6KMT2AOPRM1OPRD1SLC13A5 | |
| SCHEMBL748509 | 0.83 | LPAR1 (0.43) | LMNAMEN1KMT2ASLC13A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |