Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.39 |
| ▸ | ALPL | P05186 | 4/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480513 | 0.87 | ATM (0.41) | ALPLPDE3BPDE3ANPC1 | |
| SCHEMBL7484888 | 0.78 | ROCK2 (0.42) | LRRK2ALPLCDC7CCNE2CDK4 | |
| SCHEMBL7485161 | 0.77 | CYP17A1 (0.34) | LRRK2ALPL | |
| SCHEMBL7484067 | 0.76 | GAA (0.50) | ALPL | |
| SCHEMBL7482943 | 0.75 | HSP90AA1 (0.39) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7486190 | 0.75 | POLL (0.39) | ALPL | |
| SCHEMBL7487084 | 0.75 | HTR7 (0.41) | ALPLNPC1 | |
| SCHEMBL7685046 | 0.74 | CDC7 (0.51) | CDC7 | |
| SCHEMBL7479968 | 0.70 | ALPL (0.73) | ALPL | |
| SCHEMBL7485922 | 0.67 | PARP1 (0.50) | ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |