Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.37 |
| ▸ | ITGAV | P06756 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479429 | 0.85 | HPGD (0.49) | SMN1; SMN2HPGDHSD17B10ALDH1A1KMT2A | |
| SCHEMBL7483116 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL7480458 | 0.75 | HPGD (0.45) | SMN1; SMN2HPGDHSD17B10ALDH1A1KMT2A | |
| SCHEMBL7487235 | 0.74 | HPGD (0.47) | SMN1; SMN2HPGDHSD17B10ALDH1A1KMT2A | |
| SCHEMBL7477666 | 0.73 | GLS (0.52) | SMN1; SMN2HSD17B10ALDH1A1ITGB3ITGAV | |
| SCHEMBL7482916 | 0.72 | KMT2A (0.51) | SMN1; SMN2KDM4EALDH1A1ITGB3ITGAV | |
| SCHEMBL7475334 | 0.72 | GLS (0.53) | SMN1; SMN2ITGB3ITGAVKMT2ANPC1 | |
| SCHEMBL7478620 | 0.71 | ITGB3 (0.47) | SMN1; SMN2ALDH1A1ITGB3ITGAVKMT2A | |
| SCHEMBL7481216 | 0.71 | NPC1 (0.54) | SMN1; SMN2KDM4EALDH1A1ITGB3ITGAV | |
| SCHEMBL11389834 | 0.70 | ALDH1A1 (0.49) | SMN1; SMN2KDM4EHPGDHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |